The first hour
Disconnect from advice that arrives inside the scare screen. If someone already had remote access, assume extra software may remain even after the pop-ups disappear.
If files are encrypted and a note demands payment, do not pay from the infected machine and do not expect Thomas KC IT to negotiate. That is a different kind of incident. We can still talk about whether the PC can be rebuilt and what backups you have.
Accounts
Email is the master key because it can reset other accounts. Change it from a different device after the infected PC is cleaned or replaced. Then change banking, shopping, and work accounts you used on that computer.
Turn on multi-factor authentication where the service offers it. A cleanup that leaves the same reused password in place is incomplete.
Cleanup versus reinstall
A hijacked browser can often be repaired. A PC that will not finish booting, or one that had an unknown person controlling it, is a better candidate for a clean install once files are copied.
Kansas City customers can request that decision through malware removal. Say whether you have a backup before the appointment so nobody is surprised by a wipe.